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Snowballing Cannabis Research Gives Policy Makers the Evidence to Work With What We Know About the Plant Instead of What We Don’t Know

During 2025 over 4 000 scientific papers on cannabis were published, most with a focus on the therapeutic benefits of the plant. Advocacy group NORML says there is enough of an evidence base for policy-makers to start working with what we know about the plant instead of what we don’t know.

This report from Marijuana Moment, published on 4 December 2025.


For the fifth year in a row, researchers worldwide published more than 4,000 scientific papers related to marijuana in 2025, according to a new analysis by the advocacy group NORML.


All told, since the beginning of 2015, there have been more than 37,000 published papers about cannabis, the group said, largely reflecting “researchers’ newfound focus on marijuana’s therapeutic activities as well as investigations into the real-world effects of legalization laws.”


“Despite the perception that marijuana has yet to be subject to adequate scientific scrutiny, scientists’ interest in studying cannabis has increased exponentially in the past decade, as has our understanding of the plant, its active constituents, their mechanisms of action, and their effects on both the user and upon society,” NORML Deputy Director Paul Armentano said in a press release.


“It is time for politicians and others to stop assessing cannabis through the lens of ‘what we don’t know’ and instead start engaging in evidence-based discussions about marijuana and marijuana reform policies that are indicative of all that we do know,” he said.


Among the papers published in the past year are reports on:

 

 declining youth cannabis use in Canada post-legalization,

 lower rates of opioid prescribing in medical marijuana states,

 the therapeutic potential of cannabis to treat anxiety and depression,

 increased tourism benefits for jurisdictions that have enacted legalization 


Several other studies from 2025 have indicated that marijuana and its components can effectively mitigate alcohol use disorders and curb cravings. Researchers also found this year that more Americans use cannabis than smoke cigarettes amid shifting perceptions of harm of the two substances.

 

Also this year, scientists made strides in identifying new cannabinoids in the marijuana plant such as cannabielsoxa.

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